Efficacy of EGFR Inhibition Is Modulated by Model, Sex, Genetic Background and Diet: Implications for Preclinical Cancer Prevention and Therapy Trials

Molecule-targeted therapies are being widely developed and deployed, but they are frequently less effective in clinical trials than predicted based upon preclinical studies. Frequently, only a single model or genetic background is utilized using diets that are not relevant to that consumed by most c...

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Detalles Bibliográficos
Autores principales: Rinella, Erica S., Threadgill, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382564/
https://www.ncbi.nlm.nih.gov/pubmed/22761823
http://dx.doi.org/10.1371/journal.pone.0039552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382564/
https://www.ncbi.nlm.nih.gov/pubmed/22761823
http://dx.doi.org/10.1371/journal.pone.0039552

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