Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN

BACKGROUND: Accumulating evidence suggested that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) characteristics, both of which contribute to tumor invasion and metastasis, are interrelated with miR-21. MiR-21 is one of the important microRNAs associated with tumor progression and...

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Detalles Bibliográficos
Autores principales: Han, Mingli, Liu, Manran, Wang, Yimeng, Chen, Xin, Xu, Jianli, Sun, Yan, Zhao, Liuyang, Qu, Hongbo, Fan, Yuanming, Wu, Chengyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382593/
https://www.ncbi.nlm.nih.gov/pubmed/22761812
http://dx.doi.org/10.1371/journal.pone.0039520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382593/
https://www.ncbi.nlm.nih.gov/pubmed/22761812
http://dx.doi.org/10.1371/journal.pone.0039520

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