Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes. Breast (MDA-MB-231), lung (NCI-H358), and colon (HCT 116) carcinoma cells were transduced with shRNA to downregulate SK-1...

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Detalles Bibliográficos
Autores principales: Kotelevets, Nataliya, Fabbro, Doriano, Huwiler, Andrea, Zangemeister-Wittke, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382615/
https://www.ncbi.nlm.nih.gov/pubmed/22761740
http://dx.doi.org/10.1371/journal.pone.0039209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382615/
https://www.ncbi.nlm.nih.gov/pubmed/22761740
http://dx.doi.org/10.1371/journal.pone.0039209

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