Cargando…

Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis

Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes. Breast (MDA-MB-231), lung (NCI-H358), and colon (HCT 116) carcinoma cells were transduced with shRNA to downregulate SK-1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kotelevets, Nataliya, Fabbro, Doriano, Huwiler, Andrea, Zangemeister-Wittke, Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382615/ https://www.ncbi.nlm.nih.gov/pubmed/22761740 http://dx.doi.org/10.1371/journal.pone.0039209

Ejemplares similares

Correction: Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis
por: Kotelevets, Nataliya, et al.
Publicado: (2013)

A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders
por: Huwiler, Andrea, et al.
Publicado: (2011)

Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt
por: Schwalm, Stephanie, et al.
Publicado: (2020)

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells
por: Blanchard, Olivier, et al.
Publicado: (2018)

Lipids as Targets for Renal Cell Carcinoma Therapy
por: Stepanovska Tanturovska, Bisera, et al.
Publicado: (2023)

Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue
por: Oh, Yong-Seok, et al.
Publicado: (2015)

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
por: Olivera, Ana, et al.
Publicado: (1999)

Drugging Sphingosine Kinases
por: Santos, Webster L., et al.
Publicado: (2014)

Drosophila Polo Kinase Is Required for Cytokinesis
por: Carmena, Mar, et al.
Publicado: (1998)

Regulation of the polo kinase during cytokinesis
por: Kachaner, David
Publicado: (2015)

Biglycan- and Sphingosine Kinase-1 Signaling Crosstalk Regulates the Synthesis of Macrophage Chemoattractants
por: Hsieh, Louise Tzung-Harn, et al.
Publicado: (2017)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
por: Cannavo, Alessandro, et al.
Publicado: (2017)

Sphingosine Kinase 1 Is Required for Mesothelioma Cell Proliferation: Role of Histone Acetylation
por: Kalari, Satish, et al.
Publicado: (2012)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

Minor Kinases with Major Roles in Cytokinesis Regulation
por: Sechi, Stefano, et al.
Publicado: (2022)

Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines.
por: Zangemeister-Wittke, U., et al.
Publicado: (1998)

Sphingosine Kinase-1 Is Central to Androgen-Regulated Prostate Cancer Growth and Survival
por: Dayon, Audrey, et al.
Publicado: (2009)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina
por: Porter, Hunter, et al.
Publicado: (2018)

The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
por: Ishay, Yuval, et al.
Publicado: (2021)

An oncogenic role for sphingosine kinase 2
por: Neubauer, Heidi A., et al.
Publicado: (2016)

Sphingosine kinase 2 and multiple myeloma
por: Pyne, Nigel J., et al.
Publicado: (2017)

Transcriptional Regulation of Sphingosine Kinase 1
por: Bonica, Joseph, et al.
Publicado: (2020)

The Functional Role of Sphingosine Kinase 2
por: Diaz Escarcega, Rocio, et al.
Publicado: (2021)

Role for polo-like kinase 4 in mediation of cytokinesis
por: Press, Michael F., et al.
Publicado: (2019)

Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
por: Bhavanam, Naga P., et al.
Publicado: (2015)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells
por: Tonelli, Francesca, et al.
Publicado: (2013)

Sphingosine Kinase-2 Maintains Viral Latency and Survival for KSHV-Infected Endothelial Cells
por: Dai, Lu, et al.
Publicado: (2014)

Follicle-stimulating hormone promotes the proliferation of epithelial ovarian cancer cells by activating sphingosine kinase
por: Song, Keqi, et al.
Publicado: (2020)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
por: Matula, Kasia, et al.
Publicado: (2015)

Decreased serum concentrations of sphingosine-1-phosphate in sepsis
por: Winkler, Martin Sebastian, et al.
Publicado: (2015)

Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
por: Ng, Mei Li, et al.
Publicado: (2018)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
por: Gupta, Preeti, et al.
Publicado: (2021)

Sphingosine kinase 1 as an anticancer therapeutic target
por: Gao, Ying, et al.
Publicado: (2015)

“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer
por: Haddadi, Nahal, et al.
Publicado: (2017)

Polo-Like Kinase Controls Vertebrate Spindle Elongation and Cytokinesis
por: Brennan, Ian M., et al.
Publicado: (2007)

ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
por: Bhutta, Musab S., et al.
Publicado: (2014)

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
por: Ceccom, Johnatan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3ph2udaq64h198d3u5v0l1l03r