Reactivation of Silenced WT1 Transgene by Hypomethylating Agents - Implications for in vitro Modeling of Chemoimmunotherapy

BACKGROUND: A cell line with transfected Wilms' tumor protein 1 (WT1) is has been used for the preclinical evaluation of novel treatment strategies of WT1 immunotherapy for leukemia due to the lack of appropriate murine leukemia cell line with endogenous WT1. However, silencing of the transgene...

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Detalles Bibliográficos
Autores principales: Kwon, Yong-Rim, Son, Min-Jung, Kim, Hye-Jung, Kim, Yoo-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382665/
https://www.ncbi.nlm.nih.gov/pubmed/22740791
http://dx.doi.org/10.4110/in.2012.12.2.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382665/
https://www.ncbi.nlm.nih.gov/pubmed/22740791
http://dx.doi.org/10.4110/in.2012.12.2.58

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