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An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors
In neuromuscular acetylcholine (ACh) receptor channels (AChRs), agonist molecules bind with a low affinity (LA) to two sites that can switch to high affinity (HA) and increase the probability of channel opening. We measured (by using single-channel kinetic analysis) the rate and equilibrium constant...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382718/ https://www.ncbi.nlm.nih.gov/pubmed/22732309 http://dx.doi.org/10.1085/jgp.201210801 |