Modulation of enrofloxacin binding in OmpF by Mg(2+) as revealed by the analysis of fast flickering single-porin current

One major determinant of the efficacy of antibiotics on Gram-negative bacteria is the passage through the outer membrane. During transport of the fluoroquinolone enrofloxacin through the trimeric outer membrane protein OmpF of Escherichia coli, the antibiotic interacts with two binding sites within...

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Detalles Bibliográficos
Autores principales: Brauser, Annemarie, Schroeder, Indra, Gutsmann, Thomas, Cosentino, Cristian, Moroni, Anna, Hansen, Ulf-Peter, Winterhalter, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382719/
https://www.ncbi.nlm.nih.gov/pubmed/22689827
http://dx.doi.org/10.1085/jgp.201210776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382719/
https://www.ncbi.nlm.nih.gov/pubmed/22689827
http://dx.doi.org/10.1085/jgp.201210776

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