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Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction
p16(Ink4a) is a tumor suppressor and a marker for cellular senescence. Previous studies have shown that p16(Ink4a) plays an important role in the response to DNA damage signals caused by telomere dysfunction. In this study, we crossed Wrn(−/−) and p16(Ink4a−/−) mice to knock out the p16(Ink4a) funct...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382785/ https://www.ncbi.nlm.nih.gov/pubmed/22754337 http://dx.doi.org/10.3390/ijms13055866 |