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Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction

p16(Ink4a) is a tumor suppressor and a marker for cellular senescence. Previous studies have shown that p16(Ink4a) plays an important role in the response to DNA damage signals caused by telomere dysfunction. In this study, we crossed Wrn(−/−) and p16(Ink4a−/−) mice to knock out the p16(Ink4a) funct...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiufeng, Wu, Xiaoming, Tang, Wenru, Luo, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382785/ https://www.ncbi.nlm.nih.gov/pubmed/22754337 http://dx.doi.org/10.3390/ijms13055866

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