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Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for imped...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382849/ https://www.ncbi.nlm.nih.gov/pubmed/22737630 http://dx.doi.org/10.4161/onci.19123 |