Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche

DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for imped...

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Detalles Bibliográficos
Autor principal: Jinushi, Masahisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382849/
https://www.ncbi.nlm.nih.gov/pubmed/22737630
http://dx.doi.org/10.4161/onci.19123
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author Jinushi, Masahisa
author_facet Jinushi, Masahisa
author_sort Jinushi, Masahisa
collection PubMed
description DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for impeding tumor-specific immune responses, linking chemoresistant niche with tumor immune evasion.
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spelling pubmed-33828492012-06-26 Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche Jinushi, Masahisa Oncoimmunology Author's View DNA damage responses have been proposed as a gatekeeper to block tumorigenesis. We identify unexpected mechanisms whereby ATM-mediated pathway interacts with NFκB inflammatory cascades, leading to upregulation of integrin-αbβ3 on chemoresistant tumor cells. The integrin-αbβ3 is responsible for impeding tumor-specific immune responses, linking chemoresistant niche with tumor immune evasion. Landes Bioscience 2012-05-01 /pmc/articles/PMC3382849/ /pubmed/22737630 http://dx.doi.org/10.4161/onci.19123 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Jinushi, Masahisa
Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title_full Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title_fullStr Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title_full_unstemmed Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title_short Chronic activation of DNA damage signals causes tumor immune evasion in the chemoresistant niche
title_sort chronic activation of dna damage signals causes tumor immune evasion in the chemoresistant niche
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382849/
https://www.ncbi.nlm.nih.gov/pubmed/22737630
http://dx.doi.org/10.4161/onci.19123
work_keys_str_mv AT jinushimasahisa chronicactivationofdnadamagesignalscausestumorimmuneevasioninthechemoresistantniche

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