Targeting cancer stem cells with ALDH1A1-based immunotherapy

ALDH(bright) cells in human tumor cells lines, xenografts and lesions have been shown to have characteristics of cancer stem cells (CSC). We have shown that these cells are recognized by ALDH1A1-specific CD8(+) T cells in vitro and in vivo. The results support the potential of ALDH1A1-based immunoth...

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Detalles Bibliográficos
Autor principal: DeLeo, Albert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382868/
https://www.ncbi.nlm.nih.gov/pubmed/22737624
http://dx.doi.org/10.4161/onci.18826
Descripción
Sumario:ALDH(bright) cells in human tumor cells lines, xenografts and lesions have been shown to have characteristics of cancer stem cells (CSC). We have shown that these cells are recognized by ALDH1A1-specific CD8(+) T cells in vitro and in vivo. The results support the potential of ALDH1A1-based immunotherapy to target CSC.

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