IRF-1 is critical for IFNγ mediated immune surveillance

We recently described that IRF-1 is important for IFNγ mediated immune surveillance in metastasis. Despite the upregulation of MHC Class I in tumor cells, IRF-1 leads to a NK cell-dependent elimination of tumor cells. This mechanism is independent on inhibitory receptors and cytotoxic granules but d...

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Detalles Bibliográficos
Autores principales: Ksienzyk, Antje, Neumann, Berit, Kröger, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382888/
https://www.ncbi.nlm.nih.gov/pubmed/22754776
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author Ksienzyk, Antje
Neumann, Berit
Kröger, Andrea
author_facet Ksienzyk, Antje
Neumann, Berit
Kröger, Andrea
author_sort Ksienzyk, Antje
collection PubMed
description We recently described that IRF-1 is important for IFNγ mediated immune surveillance in metastasis. Despite the upregulation of MHC Class I in tumor cells, IRF-1 leads to a NK cell-dependent elimination of tumor cells. This mechanism is independent on inhibitory receptors and cytotoxic granules but dependent on DNAM-1.
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spelling pubmed-33828882012-07-01 IRF-1 is critical for IFNγ mediated immune surveillance Ksienzyk, Antje Neumann, Berit Kröger, Andrea Oncoimmunology Author's View We recently described that IRF-1 is important for IFNγ mediated immune surveillance in metastasis. Despite the upregulation of MHC Class I in tumor cells, IRF-1 leads to a NK cell-dependent elimination of tumor cells. This mechanism is independent on inhibitory receptors and cytotoxic granules but dependent on DNAM-1. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382888/ /pubmed/22754776 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ksienzyk, Antje
Neumann, Berit
Kröger, Andrea
IRF-1 is critical for IFNγ mediated immune surveillance
title IRF-1 is critical for IFNγ mediated immune surveillance
title_full IRF-1 is critical for IFNγ mediated immune surveillance
title_fullStr IRF-1 is critical for IFNγ mediated immune surveillance
title_full_unstemmed IRF-1 is critical for IFNγ mediated immune surveillance
title_short IRF-1 is critical for IFNγ mediated immune surveillance
title_sort irf-1 is critical for ifnγ mediated immune surveillance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382888/
https://www.ncbi.nlm.nih.gov/pubmed/22754776
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AT neumannberit irf1iscriticalforifngmediatedimmunesurveillance
AT krogerandrea irf1iscriticalforifngmediatedimmunesurveillance

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