Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients

We have developed a recombinant adenovirus vaccine encoding dopachrome tautomerase (rHuAd5-hDCT) that produces robust DCT-specific immunity, but only provides modest suppression of murine melanoma. In the current study, an agonist antibody against 4-1BB was shown to enhance rHuAd5-hDCT efficacy and...

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Detalles Bibliográficos
Autores principales: McGray, A.J. Robert, Bernard, Dannie, Hallett, Robin, Kelly, Ryan, Jha, Mayank, Gregory, Caitlin, Bassett, Jennifer D., Hassell, John A., Pare, Guillaume, Wan, Yonghong, Bramson, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382903/
https://www.ncbi.nlm.nih.gov/pubmed/22754760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382903/
https://www.ncbi.nlm.nih.gov/pubmed/22754760

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