Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy

The impact of CD27 costimulation on human T lymphocyte effector function and memory formation has been limited to evaluations using in vitro cell culture systems and observations from the clinic. We therefore investigated whether CD27 signaling augments antigen redirected human T-cell survival, expa...

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Detalles Bibliográficos
Autores principales: Song, De-Gang, Powell, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382904/
https://www.ncbi.nlm.nih.gov/pubmed/22754782
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author Song, De-Gang
Powell, Daniel J.
author_facet Song, De-Gang
Powell, Daniel J.
author_sort Song, De-Gang
collection PubMed
description The impact of CD27 costimulation on human T lymphocyte effector function and memory formation has been limited to evaluations using in vitro cell culture systems and observations from the clinic. We therefore investigated whether CD27 signaling augments antigen redirected human T-cell survival, expansion and function in vitro and in vivo.
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spelling pubmed-33829042012-07-01 Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy Song, De-Gang Powell, Daniel J. Oncoimmunology Author's View The impact of CD27 costimulation on human T lymphocyte effector function and memory formation has been limited to evaluations using in vitro cell culture systems and observations from the clinic. We therefore investigated whether CD27 signaling augments antigen redirected human T-cell survival, expansion and function in vitro and in vivo. Landes Bioscience 2012-07-01 /pmc/articles/PMC3382904/ /pubmed/22754782 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Song, De-Gang
Powell, Daniel J.
Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title_full Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title_fullStr Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title_full_unstemmed Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title_short Pro-survival signaling via CD27 costimulation drives effective CAR T-cell therapy
title_sort pro-survival signaling via cd27 costimulation drives effective car t-cell therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382904/
https://www.ncbi.nlm.nih.gov/pubmed/22754782
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