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Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in human hepatocytes integrated with the hormonal control...

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Detalles Bibliográficos
Autores principales: König, Matthias, Bulik, Sascha, Holzhütter, Hermann-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383054/
https://www.ncbi.nlm.nih.gov/pubmed/22761565
http://dx.doi.org/10.1371/journal.pcbi.1002577