CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

Previous studies have demonstrated that loss of caveolin-1 (Cav-1) in stromal cells drives the activation of the TGF-β signaling, with increased transcription of TGF-β target genes, such as connective tissue growth factor (CTGF). In addition, loss of stromal Cav-1 results in the metabolic reprogramm...

Descripción completa

Detalles Bibliográficos
Autores principales: Capparelli, Claudia, Whitaker-Menezes, Diana, Guido, Carmela, Balliet, Renee, Pestell, Timothy G., Howell, Anthony, Sneddon, Sharon, Pestell, Richard G., Martinez-Outschoorn, Ubaldo, Lisanti, Michael P., Sotgia, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383589/
https://www.ncbi.nlm.nih.gov/pubmed/22684333
http://dx.doi.org/10.4161/cc.20717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383589/
https://www.ncbi.nlm.nih.gov/pubmed/22684333
http://dx.doi.org/10.4161/cc.20717

Ejemplares similares