Large Scale Prediction and Testing of Drug Activity on Side-Effect Targets

Discovering the unintended “off-targets” that predict adverse drug reactions (ADRs) is daunting by empirical methods alone. Drugs can act on multiple protein targets, some of which can be unrelated by traditional molecular metrics, and hundreds of proteins have been implicated in side effects. We th...

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Detalles Bibliográficos
Autores principales: Lounkine, Eugen, Keiser, Michael J., Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy, Lavan, Paul, Weber, Eckhard, Doak, Allison K., Côté, Serge, Shoichet, Brian K., Urban, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383642/
https://www.ncbi.nlm.nih.gov/pubmed/22722194
http://dx.doi.org/10.1038/nature11159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383642/
https://www.ncbi.nlm.nih.gov/pubmed/22722194
http://dx.doi.org/10.1038/nature11159

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