I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

Targeted induction of double-strand breaks (DSBs) at natural endogenous loci was shown to increase the rate of gene replacement by homologous recombination in mouse embryonic stem cells. The gene encoding dopachrome tautomerase (Dct) is specifically expressed in melanocytes and their precursors. To...

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Detalles Bibliográficos
Autores principales: Fenina, Myriam, Simon-Chazottes, Dominique, Vandormael-Pournin, Sandrine, Soueid, Jihane, Langa, Francina, Cohen-Tannoudji, Michel, Bernard, Bruno A., Panthier, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383693/
https://www.ncbi.nlm.nih.gov/pubmed/22761925
http://dx.doi.org/10.1371/journal.pone.0039895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383693/
https://www.ncbi.nlm.nih.gov/pubmed/22761925
http://dx.doi.org/10.1371/journal.pone.0039895

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