Impact of Large Aggregated Uricases and PEG Diol on Accelerated Blood Clearance of PEGylated Canine Uricase

BACKGROUND: Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated uricases and cross-linked conjug...

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Detalles Bibliográficos
Autores principales: Zhang, Chun, Fan, Kai, Ma, Xuefeng, Wei, Dongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383732/
https://www.ncbi.nlm.nih.gov/pubmed/22745806
http://dx.doi.org/10.1371/journal.pone.0039659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383732/
https://www.ncbi.nlm.nih.gov/pubmed/22745806
http://dx.doi.org/10.1371/journal.pone.0039659

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