Pregnane-X-Receptor Controls Hepatic Glucuronidation During Pregnancy and Neonatal Development in Humanized UGT1 Mice

In humanized UDP glucuronosyltransferase-1 (hUGT1) mice that express the entire UGT1 locus, the maternal hepatic UGT1A genes are dramatically induced 12-14 days after conception. Steroid induction of the UGT1A1 gene indicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constit...

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Detalles Bibliográficos
Autores principales: Chen, Shujuan, Yueh, Mei-Fei, Evans, Ronald M, Tukey, Robert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Autoimmune, Cholestatic and Biliary Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383890/
https://www.ncbi.nlm.nih.gov/pubmed/22371261
http://dx.doi.org/10.1002/hep.25671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383890/
https://www.ncbi.nlm.nih.gov/pubmed/22371261
http://dx.doi.org/10.1002/hep.25671

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