Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

The presence of ribonucleotides in genomic DNA is undesirable given their increased susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such embedded ribonucleotides are present in all domains of life. However, in unicellular organisms such as budding yeast, they...

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Detalles Bibliográficos
Autores principales: Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383994/
https://www.ncbi.nlm.nih.gov/pubmed/22579044
http://dx.doi.org/10.1016/j.cell.2012.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383994/
https://www.ncbi.nlm.nih.gov/pubmed/22579044
http://dx.doi.org/10.1016/j.cell.2012.04.011

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