Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3′ Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

25/27 Base duplex RNAs that are substrates for Dicer have been demonstrated to enhance RNA interference (RNAi) potency and efficacy. Since the target sites are not always equally susceptible to suppression by small interfering RNA (siRNA), not all 27-mer duplexes that are processed into the correspo...

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Detalles Bibliográficos
Autores principales: Zhou, Jiehua, Song, Min-Sun, Jacobi, Ashley M, Behlke, Mark A, Wu, Xiwei, Rossi, John J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384246/
https://www.ncbi.nlm.nih.gov/pubmed/23343928
http://dx.doi.org/10.1038/mtna.2012.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384246/
https://www.ncbi.nlm.nih.gov/pubmed/23343928
http://dx.doi.org/10.1038/mtna.2012.6

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