Cargando…
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors
[Image: see text] There is a great demand for the discovery of new therapeutic molecules that combine the high specificity and affinity of biologic drugs with the bioavailability and lower cost of small molecules. Small, natural-product-like peptides hold great promise in bridging this gap; however,...
Autores principales: | Guillen Schlippe, Yollete V., Hartman, Matthew C. T., Josephson, Kristopher, Szostak, Jack W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2012
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384292/ https://www.ncbi.nlm.nih.gov/pubmed/22428867 http://dx.doi.org/10.1021/ja301017y |
Ejemplares similares
-
Directed
Evolution of Multivalent Glycopeptides Tightly
Recognized by HIV Antibody 2G12
por: Horiya, Satoru, et al.
Publicado: (2014) -
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
por: Hartman, Matthew C. T., et al.
Publicado: (2007) -
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
por: Pacifico, Salvatore, et al.
Publicado: (2019) -
Ribosomal Synthesis of N-Methyl Peptides
por: Subtelny, Alexander O., et al.
Publicado: (2008) -
A Selective Cyclic Peptidic Human SIRT5 Inhibitor
por: Liu, Jiajia, et al.
Publicado: (2016)