Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, w...

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Detalles Bibliográficos
Autores principales: Jayathilaka, Nimanthi, Han, Aidong, Gaffney, Kevin J., Dey, Raja, Jarusiewicz, Jamie A., Noridomi, Kaori, Philips, Michael A., Lei, Xiao, He, Ju, Ye, Jun, Gao, Tao, Petasis, Nicos A., Chen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384312/
https://www.ncbi.nlm.nih.gov/pubmed/22396528
http://dx.doi.org/10.1093/nar/gks189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384312/
https://www.ncbi.nlm.nih.gov/pubmed/22396528
http://dx.doi.org/10.1093/nar/gks189

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