Cargando…

Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2

Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development of epigenetic modulators, however, has been largely limited to direct targeting of catalytic active site conserved across multiple members of an enzyme family, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayathilaka, Nimanthi, Han, Aidong, Gaffney, Kevin J., Dey, Raja, Jarusiewicz, Jamie A., Noridomi, Kaori, Philips, Michael A., Lei, Xiao, He, Ju, Ye, Jun, Gao, Tao, Petasis, Nicos A., Chen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Gene Regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384312/ https://www.ncbi.nlm.nih.gov/pubmed/22396528 http://dx.doi.org/10.1093/nar/gks189

Ejemplares similares

Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells
por: Di Giorgio, Eros, et al.
Publicado: (2020)

Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling
por: Wales, Stephanie, et al.
Publicado: (2014)

MEF/ELF4 transactivation by E2F1 is inhibited by p53
por: Taura, Manabu, et al.
Publicado: (2011)

Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro
por: Voronova, Anastassia, et al.
Publicado: (2012)

Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
por: Minisini, Martina, et al.
Publicado: (2022)

HDAC3 functions as a positive regulator in Notch signal transduction
por: Ferrante, Francesca, et al.
Publicado: (2020)

Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition
por: Lopez-Atalaya, Jose P., et al.
Publicado: (2013)

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma
por: Lodrini, Marco, et al.
Publicado: (2013)

Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription
por: Wang, Wen-Ling, et al.
Publicado: (2008)

HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis
por: Yan, Bowen, et al.
Publicado: (2021)

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex
por: Hudson, Gregg M., et al.
Publicado: (2015)

HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells
por: Kidder, Benjamin L., et al.
Publicado: (2012)

The HDAC7–TET2 epigenetic axis is essential during early B lymphocyte development
por: Azagra, Alba, et al.
Publicado: (2022)

Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes
por: Harris, Lillianne G., et al.
Publicado: (2016)

FACT interacts with Set3 HDAC and fine-tunes GAL1 transcription in response to environmental stimulation
por: Leng, He, et al.
Publicado: (2021)

MicroRNA-26a induced by hypoxia targets HDAC6 in myogenic differentiation of embryonic stem cells
por: Lee, Sae-Won, et al.
Publicado: (2015)

Rpd3L HDAC links H3K4me3 to transcriptional repression memory
por: Lee, Bo Bae, et al.
Publicado: (2018)

HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration
por: Tang, Xiaolong, et al.
Publicado: (2020)

Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans
por: Beurton, Flore, et al.
Publicado: (2019)

Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
por: Ray, Sutapa, et al.
Publicado: (2008)

HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia
por: Gregoricchio, Sebastian, et al.
Publicado: (2022)

Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression
por: Safronova, Olga S., et al.
Publicado: (2014)

An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells
por: Wei, Tingyi, et al.
Publicado: (2015)

HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner
por: Dreval, Kostiantyn, et al.
Publicado: (2019)

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting
por: Itoh, Toshimasa, et al.
Publicado: (2015)

The dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions
por: Nanou, Aikaterini, et al.
Publicado: (2017)

NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics
por: Kim, Ji Hyun, et al.
Publicado: (2020)

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation
por: Choi, Won-Il, et al.
Publicado: (2013)

A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities
por: Banerjee, A. Raja, et al.
Publicado: (2014)

Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation
por: Ai, Nanping, et al.
Publicado: (2011)

Reconstitution of ‘floral quartets’ in vitro involving class B and class E floral homeotic proteins
por: Melzer, Rainer, et al.
Publicado: (2009)

A multipronged strategy of an anti-terminator protein to overcome Rho-dependent transcription termination
por: Muteeb, Ghazala, et al.
Publicado: (2012)

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
por: Menendez, Daniel, et al.
Publicado: (2013)

Redundancy of primary RNA-binding functions of the bacterial transcription terminator Rho
por: Shashni, Rajesh, et al.
Publicado: (2014)

Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans
por: Reed, Kailee J, et al.
Publicado: (2020)

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
por: Freudenberg, Johannes M., et al.
Publicado: (2012)

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner
por: Mishra, Vivek Kumar, et al.
Publicado: (2017)

Analysis of regulatory network topology reveals functionally distinct classes of microRNAs
por: Yu, Xueping, et al.
Publicado: (2008)

Repression of class I transcription by cadmium is mediated by the protein phosphatase 2A
por: Zhou, Lei, et al.
Publicado: (2013)

Orientation-dependent interaction between Drosophila insulators is a property of this class of regulatory elements
por: Kyrchanova, Olga, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_m2uqda0mf3pc0vhfgu6ssmte7u