Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1

Translation termination in eukaryotes is catalyzed by two release factors eRF1 and eRF3 in a cooperative manner. The precise mechanism of stop codon discrimination by eRF1 remains obscure, hindering drug development targeting aberrations at translation termination. By solving the solution structures...

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Detalles Bibliográficos
Autores principales: Wong, Leo E., Li, Yan, Pillay, Shubhadra, Frolova, Ludmila, Pervushin, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384315/
https://www.ncbi.nlm.nih.gov/pubmed/22383581
http://dx.doi.org/10.1093/nar/gks192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384315/
https://www.ncbi.nlm.nih.gov/pubmed/22383581
http://dx.doi.org/10.1093/nar/gks192

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