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The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages
We have determined the X-ray structure of the complex between the DNA quadruplex d(5′-GGGG-3′)(4) and daunomycin, as a potential model for studying drug–telomere interactions. The structure was solved at 1.08 Å by direct methods in space group I4. The asymmetric unit comprises a linear arrangement o...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384316/ https://www.ncbi.nlm.nih.gov/pubmed/22373921 http://dx.doi.org/10.1093/nar/gks193 |