Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

BACKGROUND: It has been hypothesized that early host-responses during TB treatment may paradoxically promote survival of persistent bacteria. We therefore evaluated whether adjunctive inhibition of tumor necrosis factor alpha (TNF-α)–a key cytokine in host responses against TB–could hasten bacterial...

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Detalles Bibliográficos
Autores principales: Skerry, Ciaran, Harper, Jamie, Klunk, Mariah, Bishai, William R., Jain, Sanjay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384606/
https://www.ncbi.nlm.nih.gov/pubmed/22761866
http://dx.doi.org/10.1371/journal.pone.0039680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384606/
https://www.ncbi.nlm.nih.gov/pubmed/22761866
http://dx.doi.org/10.1371/journal.pone.0039680

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