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A Magnetic Bead-Integrated Chip for the Large Scale Manufacture of Normalized esiRNAs
The chemically-synthesized siRNA duplex has become a powerful and widely used tool for RNAi loss-of-function studies, but suffers from a high off-target effect problem. Recently, endoribonulease-prepared siRNA (esiRNA) has been shown to be an attractive alternative due to its lower off-target effect...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384639/ https://www.ncbi.nlm.nih.gov/pubmed/22761791 http://dx.doi.org/10.1371/journal.pone.0039419 |