Cargando…

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis

Rac1b, an alternative splice form of Rac1, has been previously shown to be upregulated in colon and breast cancer cells, suggesting an oncogenic role for Rac1b in these cancers. Our analysis of NSCLC tumor and matched normal tissue samples indicates Rac1b is upregulated in a significant fraction of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Chun, Licciulli, Silvia, Avila, Jacqueline L., Cho, Miyoung, Troutman, Scott, Jiang, Ping, Kossenkov, Andrew, Showe, Louise C., Liu, Qin, Vachani, Anil, Albelda, Steven M., Kissil, Joseph L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384754/ https://www.ncbi.nlm.nih.gov/pubmed/22430205 http://dx.doi.org/10.1038/onc.2012.99

Ejemplares similares

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity
por: Samuel, Michael S., et al.
Publicado: (2011)

Peripheral Immune Cell Gene Expression Predicts Survival of Patients with Non-Small Cell Lung Cancer
por: Kossenkov, Andrew V., et al.
Publicado: (2012)

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac
por: Innocenti, Metello, et al.
Publicado: (2002)

A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation
por: Huang, Timothy Y., et al.
Publicado: (2013)

GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS
por: Koehn, Olivia J., et al.
Publicado: (2023)

Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma
por: Avila, Jacqueline L., et al.
Publicado: (2012)

IRF1 inhibits the proliferation and metastasis of colorectal cancer by suppressing the RAS-RAC1 pathway
por: Hong, Min, et al.
Publicado: (2018)

ContRac1ion-Mediated Glucose Uptake: A Central Role for Rac1
por: Lundell, Leonidas S., et al.
Publicado: (2013)

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms
por: Marei, Hadir, et al.
Publicado: (2016)

Rac1 S71 Mediates the Interaction between Rac1 and 14-3-3 Proteins
por: Abdrabou, Abdalla, et al.
Publicado: (2019)

Mechanistic Differences of Activation of Rac1(P29S) and Rac1(A159V)
por: Senyuz, Simge, et al.
Publicado: (2021)

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway
por: Guo, Yunshan, et al.
Publicado: (2019)

Dispensable role of Rac1 and Rac3 after cochlear hair cell specification
por: Nakamura, Takashi, et al.
Publicado: (2023)

IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models
por: Gasilina, Anjelika, et al.
Publicado: (2020)

Activating Rac
por: Tuma, Rabiya S.
Publicado: (2006)

Rac1 and Rac3 GTPases Control Synergistically the Development of Cortical and Hippocampal GABAergic Interneurons
por: Vaghi, Valentina, et al.
Publicado: (2014)

Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneurons
por: de Curtis, Ivan
Publicado: (2014)

The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling
por: Cui, Yan, et al.
Publicado: (2019)

Interplay of PKA and Rac: Fine-tuning of Rac localization and signaling
por: Bachmann, Verena A, et al.
Publicado: (2013)

Rac‐GTPases and Rac‐GEFs in neutrophil adhesion, migration and recruitment
por: Pantarelli, Chiara, et al.
Publicado: (2018)

Rac-GEF/Rac Signaling and Metastatic Dissemination in Lung Cancer
por: Cooke, Mariana, et al.
Publicado: (2020)

Rac1 takes a trip
por: Leslie, Mitch
Publicado: (2008)

Who Pix up Rac1?
por: LeBrasseur, Nicole
Publicado: (2006)

Rac1 GTPase in pancreatic cancer
por: Yan, Ying, et al.
Publicado: (2015)

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma
por: Melzer, Catharina, et al.
Publicado: (2017)

Non-Small Cell Lung Carcinoma Cell Motility, Rac Activation and Metastatic Dissemination Are Mediated by Protein Kinase C Epsilon
por: Caino, M. Cecilia, et al.
Publicado: (2012)

Rac-ing to the plasma membrane: The long and complex work commute of Rac1 during cell signaling
por: Bustelo, Xosé R., et al.
Publicado: (2012)

Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons
por: Pennucci, Roberta, et al.
Publicado: (2019)

A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association
por: Seyama, Rie, et al.
Publicado: (2023)

Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy
por: Seinen, Margien L., et al.
Publicado: (2016)

Discovery and characterization of small molecule Rac1 inhibitors
por: Arnst, Jamie L., et al.
Publicado: (2017)

Cell cycling with Rac
por: Powledge, Tabitha M.
Publicado: (2001)

An apicobasal gradient of Rac activity determines protrusion form and position
por: Couto, Africa, et al.
Publicado: (2017)

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
por: Baugher, Paige J, et al.
Publicado: (2005)

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development
por: Basso, Veronica, et al.
Publicado: (2011)

Rac1 and Rac3 GTPases Regulate the Development of Hilar Mossy Cells by Affecting the Migration of Their Precursors to the Hilus
por: Pennucci, Roberta, et al.
Publicado: (2011)

Rac1 regulates pancreatic islet morphogenesis
por: Greiner, Thomas U, et al.
Publicado: (2009)

Rac1 Deletion Causes Thymic Atrophy
por: Hunziker, Lukas, et al.
Publicado: (2011)

Putting Rac1 on the Path to Glucose Uptake
por: Rudich, Assaf, et al.
Publicado: (2013)

RAC1 Takes the Lead in Solid Tumors
por: De, Pradip, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_uc673lpr30dlts4lo92euo0rbi