Adverse Cell Culture Conditions Mimicking the Tumor Microenvironment Upregulate ABCG2 to Mediate Multidrug Resistance and a More Malignant Phenotype

ABCG2 is an efflux transporter commonly found to overexpress in multidrug resistant (MDR) cancer cells. It is also believed to be a survival factor for cancer stem cells to drive tumor growth. Tumor microenvironment represents an attractive new drug target because it allows complex interaction betwe...

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Detalles Bibliográficos
Autores principales: Cheng, Grace M. Y., To, Kenneth K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384895/
https://www.ncbi.nlm.nih.gov/pubmed/22778999
http://dx.doi.org/10.5402/2012/746025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384895/
https://www.ncbi.nlm.nih.gov/pubmed/22778999
http://dx.doi.org/10.5402/2012/746025

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