Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Receptor tyrosine kinase (RTK) signaling is frequently increased in tumor cells, sometimes as a result of decreased receptor down-regulation. The extent to which the endocytic trafficking routes can contribute to such RTK hyperactivation is unclear. Here, we show for the first time that fibroblast t...

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Detalles Bibliográficos
Autores principales: Schmees, C., Villaseñor, R., Zheng, W., Ma, H., Zerial, M., Heldin, C.-H., Hellberg, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386220/
https://www.ncbi.nlm.nih.gov/pubmed/22573884
http://dx.doi.org/10.1091/mbc.E11-04-0317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386220/
https://www.ncbi.nlm.nih.gov/pubmed/22573884
http://dx.doi.org/10.1091/mbc.E11-04-0317

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