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Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V
Receptor tyrosine kinase (RTK) signaling is frequently increased in tumor cells, sometimes as a result of decreased receptor down-regulation. The extent to which the endocytic trafficking routes can contribute to such RTK hyperactivation is unclear. Here, we show for the first time that fibroblast t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386220/ https://www.ncbi.nlm.nih.gov/pubmed/22573884 http://dx.doi.org/10.1091/mbc.E11-04-0317 |