Microtubules regulate GEF-H1 in response to extracellular matrix stiffness

Breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated contractility. In turn, matrix stiffness regulates RhoA activity. However, the upstream signaling mechanisms are poorly defined. Here we demonstrate that the Rho exchange factor GEF-H1 mediates RhoA activati...

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Detalles Bibliográficos
Autores principales: Heck, Jessica N., Ponik, Suzanne M., Garcia-Mendoza, Maria G., Pehlke, Carolyn A., Inman, David R., Eliceiri, Kevin W., Keely, Patricia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386221/
https://www.ncbi.nlm.nih.gov/pubmed/22593214
http://dx.doi.org/10.1091/mbc.E11-10-0876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386221/
https://www.ncbi.nlm.nih.gov/pubmed/22593214
http://dx.doi.org/10.1091/mbc.E11-10-0876

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