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Microtubules regulate GEF-H1 in response to extracellular matrix stiffness

Breast epithelial cells sense the stiffness of the extracellular matrix through Rho-mediated contractility. In turn, matrix stiffness regulates RhoA activity. However, the upstream signaling mechanisms are poorly defined. Here we demonstrate that the Rho exchange factor GEF-H1 mediates RhoA activati...

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Detalles Bibliográficos
Autores principales:	Heck, Jessica N., Ponik, Suzanne M., Garcia-Mendoza, Maria G., Pehlke, Carolyn A., Inman, David R., Eliceiri, Kevin W., Keely, Patricia J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386221/ https://www.ncbi.nlm.nih.gov/pubmed/22593214 http://dx.doi.org/10.1091/mbc.E11-10-0876

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