Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling

AIMS AND HYPOTHESIS: Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Ki...

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Detalles Bibliográficos
Autores principales: Gunton, Jenny E., Sisavanh, Mary, Stokes, Rebecca A., Satin, Jon, Satin, Leslie S., Zhang, Min, Liu, Sue M., Cai, Weikang, Cheng, Kim, Cooney, Gregory J., Laybutt, D. Ross, So, Trina, Molero, Juan-Carlos, Grey, Shane T., Andres, Douglas A., Rolph, Michael S., Mackay, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386271/
https://www.ncbi.nlm.nih.gov/pubmed/22761801
http://dx.doi.org/10.1371/journal.pone.0039462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386271/
https://www.ncbi.nlm.nih.gov/pubmed/22761801
http://dx.doi.org/10.1371/journal.pone.0039462

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