Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice

The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines...

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Detalles Bibliográficos
Autores principales: Wyatt, Ryan M., Tring, Elaine, Trachtenberg, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386353/
https://www.ncbi.nlm.nih.gov/pubmed/22706266
http://dx.doi.org/10.1038/nn.3134
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author Wyatt, Ryan M.
Tring, Elaine
Trachtenberg, Joshua T.
author_facet Wyatt, Ryan M.
Tring, Elaine
Trachtenberg, Joshua T.
author_sort Wyatt, Ryan M.
collection PubMed
description The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines along these stimulated neurons over weeks, we show that the specific pattern, rather than the total amount of activity, determines spine stability in awake mice.
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spelling pubmed-33863532012-12-17 Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice Wyatt, Ryan M. Tring, Elaine Trachtenberg, Joshua T. Nat Neurosci Article The stability of dendritic spines in the neocortex is profoundly influenced by sensory experience, which determines the magnitude and pattern of neural firing. By optically manipulating the temporal structure of neural activity in vivo using channelrhodopsin-2 and repeatedly imaging dendritic spines along these stimulated neurons over weeks, we show that the specific pattern, rather than the total amount of activity, determines spine stability in awake mice. 2012-06-17 /pmc/articles/PMC3386353/ /pubmed/22706266 http://dx.doi.org/10.1038/nn.3134 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wyatt, Ryan M.
Tring, Elaine
Trachtenberg, Joshua T.
Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title_full Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title_fullStr Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title_full_unstemmed Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title_short Pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
title_sort pattern, and not magnitude, of neural activity determines dendritic spine stability in awake mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386353/
https://www.ncbi.nlm.nih.gov/pubmed/22706266
http://dx.doi.org/10.1038/nn.3134
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