High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is a bacterial pathogen that claims roughly 1.4 million lives every year. Current drug regimens are inefficient at clearing infection, requiring at least 6 months of chemotherapy, and resistance to existing agents is rising. Ther...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Anuradha, Zhang, Meng, Zhu, Linyun, Liao, Reiling P., Mutai, Charles, Hafsat, Shittu, Sherman, David R., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386958/
https://www.ncbi.nlm.nih.gov/pubmed/22768185
http://dx.doi.org/10.1371/journal.pone.0039961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386958/
https://www.ncbi.nlm.nih.gov/pubmed/22768185
http://dx.doi.org/10.1371/journal.pone.0039961

Ejemplares similares