Loss of the SxxSS Motif in a Human T-Cell Factor-4 Isoform Confers Hypoxia Resistance to Liver Cancer: An Oncogenic Switch in Wnt Signaling

PURPOSE: Aberrantly activated Wnt/β-catenin signaling is important in hepatocellular carcinoma (HCC) development. Downstream gene expressions involving the Wnt/β-catenin cascade occur through T-cell factor (TCF) proteins. Here, we show the oncogenic potential of human TCF-4 isoforms based on the exp...

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Detalles Bibliográficos
Autores principales: Koga, Hironori, Tsedensodnom, Orkhontuya, Tomimaru, Yoshito, Walker, Evan J., Lee, Han Chu, Kim, Kang Mo, Yano, Hirohisa, Wands, Jack R., Kim, Miran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386968/
https://www.ncbi.nlm.nih.gov/pubmed/22768190
http://dx.doi.org/10.1371/journal.pone.0039981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386968/
https://www.ncbi.nlm.nih.gov/pubmed/22768190
http://dx.doi.org/10.1371/journal.pone.0039981

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