AID-Targeting and Hypermutation of Non-Immunoglobulin Genes Does Not Correlate with Proximity to Immunoglobulin Genes in Germinal Center B Cells

Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of expressed genes in germinal center B cells ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Gramlich, Hillary Selle, Reisbig, Tara, Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387148/
https://www.ncbi.nlm.nih.gov/pubmed/22768095
http://dx.doi.org/10.1371/journal.pone.0039601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387148/
https://www.ncbi.nlm.nih.gov/pubmed/22768095
http://dx.doi.org/10.1371/journal.pone.0039601

Ejemplares similares