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AID-Targeting and Hypermutation of Non-Immunoglobulin Genes Does Not Correlate with Proximity to Immunoglobulin Genes in Germinal Center B Cells

Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of expressed genes in germinal center B cells ar...

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Detalles Bibliográficos
Autores principales:	Gramlich, Hillary Selle, Reisbig, Tara, Schatz, David G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387148/ https://www.ncbi.nlm.nih.gov/pubmed/22768095 http://dx.doi.org/10.1371/journal.pone.0039601

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