Inhibition of CK2α Down-Regulates Hedgehog/Gli Signaling Leading to a Reduction of a Stem-Like Side Population in Human Lung Cancer Cells

Protein kinase CK2 is frequently elevated in a variety of human cancers. The Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance, and its aberrant activation has been indicated in several types of cancer, including lung cancer. In this study, we show that CK2 is positively i...

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Detalles Bibliográficos
Autores principales: Zhang, Shulin, Wang, Yucheng, Mao, Jian-Hua, Hsieh, David, Kim, Il-Jin, Hu, Li-Min, Xu, Zhidong, Long, Hao, Jablons, David M., You, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387212/
https://www.ncbi.nlm.nih.gov/pubmed/22768056
http://dx.doi.org/10.1371/journal.pone.0038996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387212/
https://www.ncbi.nlm.nih.gov/pubmed/22768056
http://dx.doi.org/10.1371/journal.pone.0038996

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