Cargando…

MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin

Preeclampsia is a major pregnancy complication, characterized by severe endothelial dysfunction, hypertension and maternal end-organ damage. Soluble endoglin is an anti-angiogenic protein released from placenta and thought to play a central role in causing the endothelial dysfunction and maternal or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaitu’u-Lino, Tu’uhevaha J., Palmer, Kirsten, Tuohey, Laura, Ye, Louie, Tong, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387233/ https://www.ncbi.nlm.nih.gov/pubmed/22768148 http://dx.doi.org/10.1371/journal.pone.0039864

Ejemplares similares

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment
por: Hannan, Natalie J., et al.
Publicado: (2017)

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta
por: Brownfoot, Fiona C., et al.
Publicado: (2016)

Therapeutic interventions: The importance of including diseased and healthy samples in preclinical studies
por: Tu'uhevaha J., Kaitu'u-Lino
Publicado: (2019)

Accuracy of Soluble Endoglin for Diagnosis of Preeclampsia and its Severity
por: Nikuei, Pooneh, et al.
Publicado: (2017)

Measuring circulating miRNAs in early pregnancy could identify fetuses’ destined to undergrow and be at increased risk of stillbirth
por: Tong, Stephen, et al.
Publicado: (2020)

Clinical tools and biomarkers to predict preeclampsia
por: MacDonald, Teresa M, et al.
Publicado: (2021)

Diagnostic and prognostic significance of serum soluble endoglin levels in preeclampsia and eclampsia
por: Sachan, Rekha, et al.
Publicado: (2016)

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia
por: Hannan, Natalie J., et al.
Publicado: (2018)

Plasma Concentrations of Soluble Endoglin versus Standard Evaluation in Patients with Suspected Preeclampsia
por: Rana, Sarosh, et al.
Publicado: (2012)

Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss
por: Kaitu'u-Lino, Tu'uhevaha J., et al.
Publicado: (2012)

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia
por: Pritchard, Natasha, et al.
Publicado: (2018)

Role of soluble endoglin in BMP9 signaling
por: Lawera, Aleksandra, et al.
Publicado: (2019)

Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling
por: Kumar, S, et al.
Publicado: (2014)

Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant
por: Bartho, Lucy A., et al.
Publicado: (2023)

Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location
por: Horne, Andrew W., et al.
Publicado: (2012)

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid
por: Hui, Lisa, et al.
Publicado: (2016)

Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
por: Hastie, Roxanne, et al.
Publicado: (2022)

Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia
por: Binder, Natalie K., et al.
Publicado: (2023)

Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury
por: Gallardo-Vara, Eunate, et al.
Publicado: (2016)

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia
por: Binder, Natalie K., et al.
Publicado: (2021)

Assessment of the Proton Pump Inhibitor, Esomeprazole Magnesium Hydrate and Trihydrate, on Pathophysiological Markers of Preeclampsia in Preclinical Human Models of Disease
por: de Alwis, Natasha, et al.
Publicado: (2022)

Circulating soluble endoglin modifies the inflammatory response in mice
por: Ruiz-Remolina, Laura, et al.
Publicado: (2017)

Endoglin: Beyond the Endothelium
por: Schoonderwoerd, Mark J. A., et al.
Publicado: (2020)

Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities
por: Pérez-Roque, Lucía, et al.
Publicado: (2020)

Placental galectin-3 is reduced in early-onset preeclampsia
por: Kandel, Manju, et al.
Publicado: (2022)

DNA Methylation of Endoglin Pathway Genes in Pregnant Women With and Without Preeclampsia
por: Rietze, Allison H, et al.
Publicado: (2020)

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction
por: Brownfoot, Fiona C., et al.
Publicado: (2019)

Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries—A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development
por: Fato, Bianca R., et al.
Publicado: (2022)

The Role of Placental Growth Factor, Soluble Endoglin, and Uterine Artery Diastolic Notch to Predict the Early Onset of Preeclampsia
por: Lubis, Muara Panusunan, et al.
Publicado: (2019)

Plasma MIC-1 and PAPP-A Levels Are Decreased among Women Presenting to an Early Pregnancy Assessment Unit, Have Fetal Viability Confirmed but Later Miscarry
por: Kaitu’u-Lino, Tu’uhevaha J., et al.
Publicado: (2013)

Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location
por: Skubisz, Monika M., et al.
Publicado: (2013)

A Bioplex Analysis of Cytokines and Chemokines in First Trimester Maternal Plasma to Screen for Predictors of Miscarriage
por: Hannan, Natalie J., et al.
Publicado: (2014)

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction – implications for treating preeclampsia
por: Kaitu’u-Lino, Tu’uhevaha J., et al.
Publicado: (2018)

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study
por: MacDonald, Teresa M., et al.
Publicado: (2018)

The Role of Endoglin in Hepatocellular Carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2021)

Endoglin in the Spotlight to Treat Cancer
por: González Muñoz, Teresa, et al.
Publicado: (2021)

Endoglin in head and neck neoplasms
por: Litwiniuk-Kosmala, Małgorzata, et al.
Publicado: (2023)

Endoglin and squamous cell carcinomas
por: Hakuno, Sarah K., et al.
Publicado: (2023)

Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia
por: Wang, Jing, et al.
Publicado: (2016)

Soluble Endoglin, Transforming Growth Factor-Beta 1 and Soluble Tumor Necrosis Factor Alpha Receptors in Different Clinical Manifestations of Preeclampsia
por: Perucci, Luiza O., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fblq00a5qjnhvambh38q88j09s