mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here, we find that Paneth cells, a key constituent of the mammalian intestinal stem cell (ISC) niche, augment stem cell function in response to calorie restriction (CR). CR acts by reducing...

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Detalles Bibliográficos
Autores principales: Yilmaz, Ömer H., Katajisto, Pekka, Lamming, Dudley W., Gültekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zukerberg, Lawrence, Bhan, Atul, Deshpande, Vikram, Sabatini, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/
https://www.ncbi.nlm.nih.gov/pubmed/22722868
http://dx.doi.org/10.1038/nature11163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387287/
https://www.ncbi.nlm.nih.gov/pubmed/22722868
http://dx.doi.org/10.1038/nature11163

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