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Auto-regulation of miRNA biogenesis by let-7 and Argonaute

MicroRNAs (miRNAs) comprise a large family of small RNA molecules that post-transcriptionally regulate gene expression in many biological pathways(1). Most miRNAs are derived from long primary transcripts that undergo processing by Drosha to produce ~65 nucleotide (nt) precursors that are then cleav...

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Detalles Bibliográficos
Autores principales: Zisoulis, Dimitrios G., Kai, Zoya S., Chang, Roger K., Pasquinelli, Amy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387326/
https://www.ncbi.nlm.nih.gov/pubmed/22722835
http://dx.doi.org/10.1038/nature11134