Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1–dependent manner

Transcription factor FoxO1 promotes hepatic glucose production. Genetic inhibition of FoxO1 function prevents diabetes in experimental animal models, providing impetus to identify pharmacological approaches to modulate its function. Altered Notch signaling is seen in tumorigenesis, and Notch antagon...

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Detalles Bibliográficos
Autores principales: Pajvani, Utpal B., Shawber, Carrie J., Samuel, Varman T., Birkenfeld, Andreas L., Shulman, Gerald I., Kitajewski, Jan, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387563/
https://www.ncbi.nlm.nih.gov/pubmed/21804540
http://dx.doi.org/10.1038/nm.2378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387563/
https://www.ncbi.nlm.nih.gov/pubmed/21804540
http://dx.doi.org/10.1038/nm.2378

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