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Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase
BACKGROUND: Hepatitis C is a treatment-resistant disease affecting millions of people worldwide. The hepatitis C virus (HCV) genome is a single-stranded RNA molecule. After infection of the host cell, viral RNA is translated into a polyprotein that is cleaved by host and viral proteinases into funct...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388044/ https://www.ncbi.nlm.nih.gov/pubmed/22768327 http://dx.doi.org/10.1371/journal.pone.0040029 |