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Probing of Exosites Leads to Novel Inhibitor Scaffolds of HCV NS3/4A Proteinase

BACKGROUND: Hepatitis C is a treatment-resistant disease affecting millions of people worldwide. The hepatitis C virus (HCV) genome is a single-stranded RNA molecule. After infection of the host cell, viral RNA is translated into a polyprotein that is cleaved by host and viral proteinases into funct...

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Detalles Bibliográficos
Autores principales:	Shiryaev, Sergey A., Cheltsov, Anton V., Strongin, Alex Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388044/ https://www.ncbi.nlm.nih.gov/pubmed/22768327 http://dx.doi.org/10.1371/journal.pone.0040029

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