Pharmacokinetics of Quinacrine Efflux from Mouse Brain via the P-glycoprotein Efflux Transporter

The lipophilic cationic compound quinacrine has been used as an antimalarial drug for over 75 years but its pharmacokinetic profile is limited. Here, we report on the pharmacokinetic properties of quinacrine in mice. Following an oral dose of 40 mg/kg/day for 30 days, quinacrine concentration in the...

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Detalles Bibliográficos
Autores principales: Ahn, Misol, Ghaemmaghami, Sina, Huang, Yong, Phuan, Puay-Wah, May, Barnaby C. H., Giles, Kurt, DeArmond, Stephen J., Prusiner, Stanley B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388068/
https://www.ncbi.nlm.nih.gov/pubmed/22768295
http://dx.doi.org/10.1371/journal.pone.0039112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388068/
https://www.ncbi.nlm.nih.gov/pubmed/22768295
http://dx.doi.org/10.1371/journal.pone.0039112

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